Neurobiology of Disease Loss of Mitochondrial Fission Depletes Axonal Mitochondria in Midbrain Dopamine Neurons

Amandine Berthet,1 Elyssa B. Margolis,2 Jue Zhang,1 Ivy Hsieh,6 X Jiasheng Zhang,6 Thomas S. Hnasko,4 Jawad Ahmad,1 Robert H. Edwards,2,3 Hiromi Sesaki,5 Eric J. Huang,3,6 and Ken Nakamura1,2,3 1Gladstone Institute of Neurological Disease, San Francisco, California 94158, 2Department of Neurology and 3Graduate Programs in Neuroscience and Biomedical Sciences, University of California, San Francisco, San Francisco, California 94158, 4Department of Neurosciences, Translational Neurosciences Institute, University of California, San Diego, La Jolla, California 92093, 5Department of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21287, and 6Department of Pathology, University of California, San Francisco, San Francisco, California 94158